| Объем | 100 мкл |
| Синонимы | E2AK3, PERK, PEK, EIF2AK3, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9NZJ5 |
| Иммуноген | Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | <p>Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)<br/><br/>Shi Y., An J., J. Biol. Chem. 274:5723-5730(1999).<br />Sood R., Biochem. J. 346:281-293(2000).<br />The MGC Project Team, Genome Res. 14:2121-2127(2004).<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Thr981 |
| Области исследований | Epigenetics and Nuclear Signaling,Metabolism |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissue using PEK/PERK (Phospho-Thr982) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Наименование: Phospho-EIF2AK3 (Thr981) Antibody.