| Объем | 100 мкл |
| Синонимы | DOK1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q99704 |
| Иммуноген | Peptide sequence around phosphorylation site of tyrosine 398 (E-G-Y(p)-E-L) derived from Human p62Dok. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 |
| Примечание | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.<br/><br/>Michael J. Wick, et al. (2001) J. Biol. Chem , 276: 42843 - 42850.<br/>Paul D. Simoncic, et al. (2006) Mol. Cell. Biol , 26: 4149 - 4160.<br/>Nadia Dub |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Tyr398 |
| Области исследований | Cancer,Cardiovascular,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from K562 cells untreated or treated with H2O2 using p62Dok(phospho-Tyr398) Antibody.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p62Dok(Phospho-Tyr398) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: Phospho-DOK1 (Tyr398) Antibody.