| Объем | 100 мкл |
| Синонимы | KIAA1264, p21-activated kinase 7, PAK 7, PAK-5, PAK-7 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9P286 |
| Иммуноген | Synthesized peptide derived from C-terminal of human PAK7. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.<br/><br/>Pandey A., Oncogene 21:3939-3948(2002).<br/>Nagase T., DNA Res. 6:337-345(1999).<br/>Deloukas P., Nature 414:865-871(2001).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Neuroscience,Cell biology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from rat brain cells, using PAK7 antibody.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PAK7 antibody.
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Наименование: PAK7 Antibody.