Phospho-CBL (Tyr674) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | C-CBL, CBL2, Proto-oncogene c-Cbl, RNF55, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P22681 | | Иммуноген | Peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y(p)-S-L) derived from Human CBL. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.<br/><br/>Fernandes MS, et al. (2010) J Biol Chem 285, 32596-605 <br />Teckchandani AM, Panetti TS, Tsygankov AY (2005) Exp Cell Res 307, 247-58 </p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr674 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells treated with Na2VO3 using Phospho-CBL (Tyr674) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA574497 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-CBL (Tyr674) Antibody.
Примечание: дополнительная информация (на английском языке). |
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