PRKAB1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | 5-AMP-activated protein kinase subunit beta-1, AMPK beta-1 chain, AMPKb, PRKAB1, AMPK | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9Y478 | | Иммуноген | Synthesized peptide derived from N-terminal of human PRKAB1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).<br/><br/>Stapleton D., FEBS Lett. 409:452-456(1997).<br/>Scherer S.E., Nature 440:346-351(2006).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cardiovascular,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from RAW264.7 cells, treated with TNF (20ng/ml, 5mins), using PRKAB1 antibody.
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Наименование: PRKAB1 Antibody.