Phospho-TP53 (Ser33) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | P53, BCC7, LFS1, TRP53 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04637 | | Иммуноген | Peptide sequence around phosphorylation site of serine 33 (V-L-S(p)-P-L) derived from Human p53. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 | | Примечание | <p>Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. <br /><br />Lin T, et al. (2005) Nat Cell Biol, 7(2): 165-71. <br />Vega FM, et al. (2004) Mol Cell Biol, 24(23): 10366-80. <br />Li J, et al. (2004) J Biol Chem, 279(40): 41275-9. <br />Wang J, et al. (2004) J Biol Chem, 279(38): 39584-92.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser33 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 cells using p53(Phospho-Ser33) Antibody and the same antibody preincubated with blocking peptide.
 | Immunofluorescence staining of methanol-fixed Hela cells using p53(Phospho-Ser33) Antibody.
 | Western blot analysis of extracts from HT29 cells, treated with serum or calf intestinal phosphatase (CIP), using p53 (Phospho-Ser33) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA029276 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-TP53 (Ser33) Antibody.
Примечание: дополнительная информация (на английском языке). |
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