Phospho-SNAI1 (Ser246) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | SNAH, SNAI, Sna, Snail, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O95863 | | Иммуноген | Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 | | Примечание | <p>Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.<br/><br/>Okubo T., Cancer Res. 61:1338-1346(2001).<br />Twigg S.R., Hum. Genet. 105:320-326(1999).<br />Paznekas W.A., Genomics 62:42-49(1999).<br /></p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser246 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 cells using SNAI1 (Phospho-Ser246) Antibody.The lane on the right is treated with the antigen-specific peptide.
 | Immunofluorescence staining of methanol-fixed HuvEc cells using SNAI1 (Phospho-Ser246) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA298000 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-SNAI1 (Ser246) Antibody.
Примечание: дополнительная информация (на английском языке). |
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