Phospho-NTRK1 (Tyr791) Antibody

Спецификация

Объем	100 мкл
Синонимы	TRKA, TRK, NTRK1, p140-TrkA,
Клональность	Polyclonal Antibody
Организм	Human
uniprot	P04629
Иммуноген	Peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y(p)-L-D) derived from Human Trk A.
Источник	Rabbit
Видовая специфичность	Human
Применение	ELISA, IHC,IHC:1:50-1:100
Примечание	<p>Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.<br/><br/>Tina Garofalo, J. Biol. Chem., Dec 1998, 273: 35153.<br />Jan Grimm, J. Cell Biol., Jul 2001, 154: 345.<br />Jose L. Tomsig, J Androl, May 2006, 27: 348 - 357.<br />VI Shifrin and BG Neel J. Biol. Chem., Dec 1993, 268: 25376 - 25384<br /></p>
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Абревеатура	Phospho-Tyr791
Области исследований	Others
Ссылка на страницу на сайте производителя	ссылка
Immunohistochemical analysis of paraffin-embedded human brain tissue, using Trk A (phospho-Tyr791) antibody (left)or the same antibody preincubated with blocking peptide (right).

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	100 мкл
	Кат. номер:	CSB-PA078103
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Phospho-NTRK1 (Tyr791) Antibody. Примечание: дополнительная информация (на английском языке).