| Объем | 100 мкл |
| Синонимы | High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK, TRK1 transforming tyrosine kinase protein |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P04629 |
| Иммуноген | Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 |
| Примечание | Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.<br/><br/>Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23, 104(43):17210-5.<br/>Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24,104(30):12270-5<br/>Inoue K, et al. J Biol Chem. 2007 Aug 17,282(33):24175-84<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser791 |
| Области исследований | Others |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Rat and Mouse brain tissue using TrkA(Phospho-Ser791) Antibody.
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Immunofluorescence staining of methanol-fixed Hela cells using TrkA(Phospho-Ser791) Antibody.
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Наименование: Phospho-NTRK1 (Ser791) Antibody.