| Объем | 100 мкл |
| Синонимы | CAP20, CDK-interacting protein 1, CDKN1, CDKN1A, CDN1A |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P38936 |
| Иммуноген | Peptide sequence around phosphorylation site of threonine 145 (R-Q-T(p)-S-M) derived from Human p21Cip1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.<br/><br/>Ocker M Int,et al. (2007)J Biochem Cell Biol. 39(7-8):1367-74.<br/>Dangi S, et al.(2006)Cell Prolif. 39(4):261-79.<br/>Chen J,et al.(2006)Am J Physiol Heart Circ Physiol. 290(4):H1575-86<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Thr145 |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p21Cip1(Phospho-Thr145) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: Phospho-CDKN1A (Thr145) Antibody.