| Объем | 100 мкл |
| Синонимы | BIG2, brefeldin A-inhibited GEP 2, brefeldin A-inhibited guanine nucleotide-exchange protein 2, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9Y6D5 |
| Иммуноген | Synthesized peptide derived from internal of human ARFGEF2. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 |
| Примечание | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles, the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.<br/><br/>Togawa A., J. Biol. Chem. 274:12308-12315(1999).<br/>Deloukas P., Nature 414:865-871(2001).<br/>Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004)<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Neuroscience,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from A549 cells, using ARFGEF2 antibody.
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Immunofluorescence analysis of A549 cells, using ARFGEF2 antibody.
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Наименование: ARFGEF2 Antibody.