PAK1/PAK2/PAK3 (Ab-423/402/421) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 2.7.11.1, Gamma-PAK, P21-activated kinase 2, PAK 2, PAK-2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13153/Q13177/O75914 | | Иммуноген | Synthesized non-phosphopeptide derived from human PAK1/2/3 around the phosphorylation site of threonine 423/402/421 (R-S-T(p)-M-V). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.<br/><br/>Bernadett Boda, J. Neurosci., Dec 2004, 24: 10816 - 10825. <br/>Donna L. McPhie, J. Neurosci., Jul 2003, 23: 6914. <br/>Jin-Hun Jung, J. Biol. Chem., Dec 2005, 280: 40025 - 40031. <br/>Guo-Lei Zhou, Mol. Cell. Biol., Nov 2003, 23: 8058 - 8069.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemistry analysis of paraffin-embedded human brain tissue using PAK1/2/3 (Ab-423/402/421) antiobdy.
 | Western blot analysis of extracts from NIH-3T3 cells, using PAK1/2/3 (Ab-423/402/421) antibody.
 | Western blot analysis of extracts from 293 cells (Lane 2), using PAK1/2/3 (Ab-423/402/421) antiobdy. The lane on the left is treated with synthesized peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA089760 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: PAK1/PAK2/PAK3 (Ab-423/402/421) Antibody.
Примечание: дополнительная информация (на английском языке). |
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