| Объем | 100 мкл |
| Синонимы | Probable DNA dC->dU-editing enzyme APOBEC-3D, EC 3.5.4.-, APOBEC3D, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q96AK3/Q8IUX4 |
| Иммуноген | Synthesized peptide derived from internal of human APOBEC3D/F. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.<br/><br/>Dunham I., Nature 402:489-495(1999).<br/>Jarmuz A., Genomics 79:285-296(2002).<br/>Wedekind J.E., Trends Genet. 19:207-216(2003).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from MCF-7 cells and COS-7cells, using APOBEC3D/F antibody.
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Immunohistochemistry analysis of paraffin-embedded human placenta tissue using APOBEC3D/F antibody.
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Наименование: APOBEC3D/APOBEC3F Antibody.