MCU AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A), MCU, C10orf42 CCDC109A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q8NE86 | | Иммуноген | Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC, Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200 | | Примечание | Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2, at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Calcium uniporter protein, mitochondrial | | Области исследований | Cardiovascular, Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western Blot
Positive WB detected in: HL60 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: MCU antibody at 3.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40, 37, 36 kDa
Observed band size: 40 kDa
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA847694LA01HU at dilution of 1:100
 | Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA847694LA01HU at dilution of 1:100
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Наименование: MCU Antibody.