Map2k5 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | MAP kinase kinase 5, Map2k5, MAPKK 5, MAPK/ERK kinase 5, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q62862 | | Иммуноген | Peptide sequence around aa. 311-315(K-T-Y-V-G ) derived from Rat MEK5. | | Источник | Rabbit | | Видовая специфичность | Human, Rat, Mouse | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7)phosphorylates and activates the JNK signal transduction pathway.<br/><br/> Han, J., et al. 1996. J. Biol. Chem. 271: 2886-2891.<br/>Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926.<br/>Tournier, C., et al. 1997. Proc. Natl. Acad. Sci. USA94: 7337-7442.<br/> Holland, P.M., et al. 1997. J. Biol. Chem. 272: 24994-24998. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from rat brain and mouse brain tissue using MEK5 Antibody
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Наименование: Map2k5 Antibody.