LIMK1 Antibody, Biotin conjugatedСпецификация| Объем | 50 мкг | | Синонимы | LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1), LIMK1, LIMK | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P53667 | | Иммуноген | Recombinant Human LIM domain kinase 1 protein (179-320AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | LIM domain kinase 1 | | Области исследований | Neuroscience, Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA012952LD01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: LIMK1 Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
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