| Объем | 100 мкл |
| Синонимы | NBN |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O60934 |
| Иммуноген | Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 |
| Примечание | Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.<br/><br/>Hsu HL, et al (2005)Oncogene, 24(31): 4956-64.<br/>Falck J, et al. (2005) Nature, 434(7033): 605-11.<br/>Buscemi G, et al. (2004) Oncogene, 23(46): 7691-700.<br/>Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A, 101(33): 12130-5. <br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Jurkat cells using p95/NBS1(Ab-343) Antibody and the same antibody preincubated with blocking peptide.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p95/NBS1(Ab-343) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: NBN (Ab-343) Antibody.