KDM4D AntibodyСпецификация| Объем | 100 мкл | | Синонимы | lysine (K)-specific demethylase 4D | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q6B0I6 | | Иммуноген | Fusion protein of human KDM4D | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 | | Примечание | JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA953461(KDM4D Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ?200)
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA953461(KDM4D Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ?200)
 | Gel: 8%SDS-PAGE, Lysate: 40 ?g, Lane: Human fetal brain tissue, Primary antibody: CSB-PA953461(KDM4D Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
 | | | |
Информация для заказа |
Наименование: KDM4D Antibody.