| Объем | 100 мкл |
| Синонимы | Integrin beta-7 (Gut homing receptor beta subunit), ITGB7 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P26010 |
| Иммуноген | Recombinant Human Integrin beta-7 protein (1-140AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC, Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
| Примечание | Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen Affinity Purified |
| Абревеатура | Integrin beta-7 |
| Области исследований | Signal transduction, Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot
All lanes: ITGB7 antibody at 5.04µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: A549 whole cell lysate
Lane 4: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 87, 72 kDa
Observed band size: 87 kDa
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Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011891ESR1HU at dilution of 1:100
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Наименование: ITGB7 Antibody.