IKBKG (Ab-85) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FIP-3, FIP3, I-kappa-B kinase gamma, IKBKG, IKK-gamma | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9Y6K9 | | Иммуноген | Synthesized non-phosphopeptide derived from human IKK-gamma around the phosphorylation site of serine 85 (Q-A-S(p)-Q-R). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response, this function requires 'Lys-27'-linked polyubiquitination.<br/><br/>Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).<br/>Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).<br/>Rothwarf D.M., Nature 395:297-300(1998).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular,Cell biology,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells, treated with Anisomycin (0.5uM, 5hours), using IKK-? (Ab-85) antibody.
 | Immunofluorescence analysis of HeLa cells, using IKK-? (Ab-85) antibody.
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Наименование: IKBKG (Ab-85) Antibody.