JUP AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CTNNG, DP3, Desmoplakin III, JUP, Junction plakoglobin | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P14923 | | Иммуноген | Synthesized peptide derived from human Catenin-gamma. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.<br/><br/>T Naka, J. Clin. Pathol., Dec 2001, 54: 945 - 950.<br/>AR Burns, J. Immunol., Sep 1997, 159: 2893.<br/>Frank T. Kolligs, Genes & Dev., Jun 2000, 14: 1319.<br/>Jon A. Ukropec, J. Biol. Chem., Feb 2000, 275: 5983. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Catenin-? antibody.
 | Western blot analysis of extracts from HeLa cells, using Catenin-? antibody.
 | Western blot analysis of extracts from HuvEc cells (Lane 2), using Catenin-? antiobdy. The lane on the left is treated with systhesized peptide.
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Наименование: JUP Antibody.