IFIH1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Interferon-induced helicase C domain-containing protein 1, EC 3.6.1.-, Interferon-induced with helicase C domain protein 1, Helicase with 2 CARD domains, Helicard | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9BYX4 | | Иммуноген | Synthesized peptide derived from C-terminal of human IFIH1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs), IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.<br/><br/>Kang D.-C., Proc. Natl. Acad. Sci. U.S.A. 99:637-642(2002).<br/>Cocude C., J. Gen. Virol. 84:3215-3225(2003).<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Immunology,Microbiology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells, using IFIH1 antibody.
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Наименование: IFIH1 Antibody.