| Объем | 50 мкг |
| Синонимы | Latent membrane protein 2 (Terminal protein), LMP2 |
| Клональность | Polyclonal Antibody |
| Организм | Epstein-Barr virus |
| uniprot | P13285 |
| Иммуноген | Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA) |
| Источник | Rabbit |
| Видовая специфичность | Epstein-Barr virus |
| Применение | ELISA, WB, Recommended dilution: WB:1:200-1:2000 |
| Примечание | Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | Latent membrane protein 2 |
| Области исследований | Others |
| Ссылка на страницу на сайте производителя | ссылка |
Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue
All lanes: LMP2 antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54, 41 kDa
Observed band size: 54 kDa
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Наименование: LMP2 Antibody.