HERC5 Antibody, HRP conjugatedСпецификация| Объем | 100 мкг | | Синонимы | E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5), HERC5, CEB1 CEBP1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9UII4 | | Иммуноген | Recombinant Human E3 ISG15--protein ligase HERC5 protein (153-284AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence, ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | HRP | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | E3 ISG15--protein ligase HERC5 | | Области исследований | Epigenetics and Nuclear Signaling, Cell biology, Immunology | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкг | | Кат. номер: | CSB-PA883435LB01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: HERC5 Antibody, HRP conjugated.
Примечание: дополнительная информация (на английском языке). |
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