| Объем | 100 мкл |
| Синонимы | Insulin receptor substrate-1, IRS-1, IRS1, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P35568 |
| Иммуноген | Synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Примечание | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.<br/><br/>Araki E., Diabetes 42:1041-1054(1993).<br/>Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004)<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Neuroscience,Cancer,Cardiovascular,Tags & Cell Markers,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 (Ab-312) antibody.
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Immunofluorescence analysis of HeLa cells, using IRS-1 (Ab-312) antibody.
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Western blot analysis of extracts from NIH-3T3 cells, using IRS-1 (Ab-312) antibody.
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Western blot analysis of extracts from JK cells (Lane 2), using IRS-1 (Ab-312) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: IRS1 (Ab-312) Antibody.