| Объем | 100 мкл |
| Синонимы | GABJ, GRB2-associated binding protein 2, KIAA0571, pp100, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9UQC2 |
| Иммуноген | Synthesized non-phosphopeptide derived from human GRB2 around the phosphorylation site of serine 159 (K-S-S(p)-A-P). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.<br/><br/>Nishida K., Blood 93:1809-1816(1999).<br/>Nagase T., DNA Res. 5:31-39(1998).<br/>Taylor T.D., Nature 440:497-500(2006).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Neuroscience,Cancer,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using GRB2 (Ab-159) antibody.
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Western blot analysis of extracts from COS cells, using GRB2 (Ab-159) antibody.
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Western blot analysis of extracts from 293 cells (Lane 2), using Gab2 (Ab-159) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: GAB2 (Ab-159) Antibody.