| Объем | 100 мкл |
| Синонимы | CD135, FLK-2, FLT-3, FLT3, STK-1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P36888 |
| Иммуноген | Peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 |
| Примечание | FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.<br/><br/>Sekine S et,al. (2008) J Immunol. ,180(12):8126-34<br/>Pratz K et,al. (2008) Leuk Lymphoma. 2008 ,49(5):852-63.<br/>Al Shaer L et,al. (2008) Br J Haematol. 141(4):483-93.<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Immunology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 and MCF cells using FLT3(Ab-591) Antibody.
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Immunofluorescence staining of methanol-fixed Hela cells using FLT3(Ab-591) Antibody.
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Наименование: FLT3 (Ab-591) Antibody.