| Объем | 100 мкл |
| Синонимы | HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate, IMOS-1, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O14964 |
| Иммуноген | Synthesized peptide derived from internal of human HGS. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Примечание | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.<br/><br/>Asao H., J. Biol. Chem. 272:32785-32791(1997).<br/>Lu L., Gene 213:125-132(1998).<br/>Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Cell biology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 cells and JK cells, using HGS antibody.
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Immunohistochemistry analysis of paraffin-embedded human testis tissue using HGS antibody.
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Immunofluorescence analysis of HUVEC cells, using HGS antibody.
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Наименование: HGS Antibody.