| Объем | 50 мкл |
| Синонимы | Fas (TNFRSF6)-associated via death domain |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13158 |
| Иммуноген | Fusion protein of human FADD |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC,ELISA:1:1000-1:5000, IHC:1:50-1:150 |
| Примечание | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen affinity purification |
| Области исследований | Cancer,Cell biology |
| Ссылка на страницу на сайте производителя | ссылка |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA221364(FADD Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ?200)
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The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA221364(FADD Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ?200)
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Наименование: FADD Antibody.