| Объем | 100 мкл |
| Синонимы | 3-5 exoribonuclease 1, 3-5 exonuclease ERI1, Eri-1 homolog, Histone mRNA 3-end-specific exoribonuclease, Histone mRNA 3-exonuclease 1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q8IV48 |
| Иммуноген | Synthesized peptide derived from internal of human ERI1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.<br/><br/>Dominski Z., Mol. Cell 12:295-305(2003).<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/>Bechtel S., BMC Genomics 8:399-399(2007)<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from COLO205 cells, using ERI1 antibody.
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Наименование: ERI1 Antibody.