| Объем | 100 мкл |
| Синонимы | CAR, Coxsackievirus and adenovirus receptor precursor, Coxsackievirus B- adenovirus receptor, CVB3 binding protein, CXAR |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P78310 |
| Иммуноген | Synthesized peptide derived from internal of human CXADR. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.<br/><br/>Tomko R.P., Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997).<br/>Bergelson J.M., Science 275:1320-1323(1997).<br/>Bowles K.R., Hum. Genet. 105:354-359(1999).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Microbiology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from COLO cells and HepG2 cells, using CXADR antibody.
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Наименование: CXADR Antibody.