| Объем | 100 мкл |
| Синонимы | Dickkopf-related protein 3, Dkk-3, Dickkopf-3, hDkk-3, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9UBP4 |
| Иммуноген | Synthesized peptide derived from internal of human DKK3. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease By similarity.<br/><br/>Shimizu K., Gene 282:151-158(2002).<br/>Gray A.M., Genome Res. 13:2265-2270(2003).<br/>Niehrs C., Oncogene 25:7469-7481(2006).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Signal transduction,Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Jurkat cells, using DKK3 antibody.
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Наименование: DKK3 Antibody.