CLNS1A AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Methylosome subunit pICln, Chloride conductance regulatory protein ICln, I(Cln), Chloride channel, nucleotide sensitive 1A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P54105 | | Иммуноген | Synthesized peptide derived from C-terminal of human CLNS1A. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.<br/><br/>Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996).<br/>Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995).<br/>Lamb F.S., Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cardiovascular | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HuvEc cells, K562 cells, HeLa cells, HepG2 cells, A549 cells and Jurkat cells, using CLNS1A antibody.
 | | | |
Информация для заказа |
Наименование: CLNS1A Antibody.