DDR1 (Ab-796) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CAK, CD167, CD167 antigen-like family member A, Cell adhesion kinase, DDR | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q08345 | | Иммуноген | Synthesized non-phosphopeptide derived from human DDR1 around the phosphorylation site of tyrosine 796. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.<br/><br/>di Marco E., J. Biol. Chem. 268:24290-24295(1993).<br/>Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993).<br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from JK cells (Lane 2), using DDR1 (Ab-796) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: DDR1 (Ab-796) Antibody.