CLDN1 (Ab-210) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CLD1, CLDN1, SEMP1, Senescence-associated epithelial membrane protein, UNQ481/PRO944 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O95832 | | Иммуноген | Synthesized non-phosphopeptide derived from human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.<br/><br/>Swisshelm K.L., Gene 226:285-295(1999).<br/>Halford S., Cytogenet. Cell Genet. 88:217-217(2000).<br/>Kraemer F., Hum. Genet. 107:249-256(2000).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, treated with Hu (2nM, 24hours), using Claudin 1 (Ab-210) antibody.
 | Western blot analysis of extracts from JK cells (Lane 2), using Claudin 1 (Ab-210) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: CLDN1 (Ab-210) Antibody.