CD22 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | SIGLEC2, FLJ22814, SIGLEC-2, MGC130020, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P20273 | | Иммуноген | Peptide sequence around aa.839~843 (N-V-D-Y-V) derived from Human CD22. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.<br/><br/>Doody G.M., Justement L.B., Delibrias C.C., Matthews R.J., Lin J., Thomas M.L., Fearon D.T. Science 269:242-244(1995) <br/>Tuscano J.M., Engel P., Tedder T.F., Agarwal A., Kehrl J.H.Eur. J. Immunol. 26:1246-1252(1996) <br/>Law C.L., Sidorenko S.P., Chandran K.A., Zhao Z., Shen S.H., Fischer E.H., Clark E.A.J. Exp. Med. 183:547-560(1996) | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Immunology,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from Raji cells using CD22 Antibody
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Наименование: CD22 Antibody.