| Объем | 100 мкл |
| Синонимы | APFL, aprataxin and PNK-like factor, C2orf13, Xip1, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q8IW19 |
| Иммуноген | Synthesized non-phosphopeptide derived from human APLF around the phosphorylation site of serine 116 (R-N-S(p)-Q-V). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.<br/><br/>Saunders W.S., J. Cell Sci. 104:573-582(1993).<br/>Ye Q., J. Biol. Chem. 271:14653-14656(1996).<br/>Ye Q., J. Biol. Chem. 272:14983-14989(1997).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry analysis of paraffin-embedded human brain tissue using APLF (Ab-116) antibody.
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Western blot analysis of extracts from HT-29 cells, using APLF (Ab-116) antibody.
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Western blot analysis of extracts from COS7 cells (Lane 2), using APLF (Ab-116) antiobdy. The lane on the left is treated with systhesized peptide.
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Наименование: APLF (Ab-116) Antibody.