AATF AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CHE-1, CHE1, DED, apoptosis antagonizing transcription factor, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9NY61 | | Иммуноген | Synthesized peptide derived from N-terminal of human AATF. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.<br/><br/>Lindfors K., Biochem. Biophys. Res. Commun. 276:660-666(2000).<br/>Fanciulli M., FASEB J. 14:904-912(2000).<br/>Di Padova M., J. Biol. Chem. 278:36496-36504(2003).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, HepG2 cells, COLO205 cells and HUVEC cells, using AATF antibody.
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Наименование: AATF Antibody.