Rabbit Anti Human TNF PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | TNF , TNFSF2, DIF, Tumor necrosis factor, TNF a, TNF alpha | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P01375 | | Иммуноген | C term -peptide of human SFPQ | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:1000-1:2000, IHC:1:50-1:100 | | Примечание | TNF-alpha, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. Membrane-bound TNF-alpha is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer. Both membrane and soluble forms of TNF-alpha are biologically active. TNF-alpha is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages. Cellular response to TNF-alpha is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-κB) promotes the survival of cells, while TNF-alpha-mediated activation of caspase-8 leads to programmed cell death. TNF-alpha plays a key regulatory role in inflammation and host defense against bacterial infection, notably Mycobacterium tuberculosis. The role of TNF-alpha in autoimmunity is underscored by blocking TNF-alpha action to treat rheumatoid arthritis and Crohn’s disease. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Cancer,Cardiovascular,Immunology,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of Hela and NIH3T3 cells, using TNF? antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA023955KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human TNF PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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