Антитела Anti-CD161 antibody [3.2.3] (BSA and Azide free), мышиные моноклональные

Anti-CD161 antibody [3.2.3] - BSA and Azide free

Product nameAnti-CD161 antibody [3.2.3] - BSA and Azide free
See all CD161 primary antibodies
Description
Mouse monoclonal [3.2.3] to CD161 - BSA and Azide free
Tested applicationsELISA, IP, Blocking, ICC, Flow Cyt, IHC-Pmore details
Species reactivity
Reacts with: Rat
Immunogen
Full length protein corresponding to Rat CD161.
Database link: P27471
General notes
Low endotoxin.

FormLiquid
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Concentration500 µg at 0.506 mg/ml
PurityIgG fraction
Purification notesPurified IgG from ascites fluid.
ClonalityMonoclonal
Clone number3.2.3
IsotypeIgG1
Light chain typekappa
Research areas

Our Abpromise guarantee covers the use of ab175313 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application	Abreviews	Notes
ELISA		Use at an assay dependent concentration.
IP		Use at an assay dependent concentration.
Blocking		Use at an assay dependent concentration.
ICC		Use at an assay dependent concentration.
Flow Cyt		Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-P		Use at an assay dependent concentration.

FunctionPlays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Tissue specificityExpressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Sequence similaritiesContains 1 C-type lectin domain.
Post-translational
modificationsN-glycosylated. Contains sialic acid residues.
Cellular localizationMembrane.
Information by UniProt
Database links
- Entrez Gene: 689817 Rat
- SwissProt: Q0ZUP0 Rat
- Unigene: 198693 Rat
Alternative names
- C-type lectin domain family 5 member B antibody
- CD161 antibody
- CLEC5B antibody
see all

ab175313 has not yet been referenced specifically in any publications.

Область использования: Прочие реагенты для иммуногистохимии	Производство:	Abcam
	Метод:
	Объем:	100 мг
	Кат. номер:	ab175313
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела Anti-CD161 antibody [3.2.3] (BSA and Azide free), мышиные моноклональные / Anti-CD161 antibody [3.2.3] - BSA and Azide free. Примечание: