Rabbit Anti Human MSR1 PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | MSR1, SRA, SR-A, CD204, phSR1, phSR2, SCARA1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P21757 | | Иммуноген | Recombinant protein of human MSR1 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:2000, IHC:1:50-1:200 | | Примечание | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Cancer,Cardiovascular,Immunology,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts of various cell lines, using MSR1 antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA015050KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human MSR1 PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
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