Rabbit Anti Human CCND1 PolyClonal AntibodyСпецификация| Объем | 100 мкл (100 мкг) | | Синонимы | CCND1,BCL1,D11S287E,PRAD1,U21B31,G1/S-specific cyclin-D1,BCL-1 oncogene ,PRAD1 oncogene | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P24385 | | Иммуноген | A synthetic peptide of Human Cyclin D1 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, ICC, IP,WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100, IP:1:20-1:50 | | Примечание | Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to effect progression through the restriction point and pRb-dependent entry into S-phase. The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of its protein expression and through phosphorylation-dependent degradation. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Affinity purification | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of MCF-7 cell lysate ,using Cyclin D1 antibody.
 | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | | | Объем: | 100 мкл (100 мкг) | | Кат. номер: | CSB-PA004811KA01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Rabbit Anti Human CCND1 PolyClonal Antibody.
Примечание: дополнительная информация (на английском языке). |
|
